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KMID : 0390119940340020245
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Journal of Pusan Medical College
1994 Volume.34 No. 2 p.245 ~ p.258
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Detection of Mycobacterium tuberculosis DNA Using the Polymerase Chain Reaction in Paraffin-Embedded Biopsy Specimens of Tuberculids
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Abstract
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The cause and classification of tuberculids are still controversial. At present, the most acceptable dermatoses related to an infection with tuberculosis are erythema induratum, papulonecrotic tuberculid and lichen scrofulosorum, while lupus
miliaris
disseminatus taciei as a clinical expression of granulomatous rosacea, is no longer considered tuberculid.
In order to clarify the causal relationship of Mycobacterium tuberculosis to the development of tuberculid, we examined sections from 19 formalin-fixed, parafin-embedded skin biopsy specimens from 19 patients with tuberculids comprising 15
erythema
induratum and 2 papulonecrotic tuberculid, and 2 lupus miliaris disseminatus faciei for the detection of Mycobacterium tuberculosis DNA by polymerase chain reaction.
Mycobacterium tuberculosis DAN was detected in 14 specimens(73.6%) out of total 19 specimens examined ; 10(66.6%) of 15 erythema induratum, 2(10%) of 2 papulonecrotic taberculid and 2(100%) of 2 lupu s miliaris disseminatus faciei.
These findings provide strong evidence that Mycobacterium tubderculosis is in some way responsible for the developmont of tuberculids. It is also suggested that despite we examined only 2 cases, lupus miliaris disseminatus faciei should be
considered
thoughtfully in diagnosis and classification of tuberculids.
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